The role of the medial prefrontal cortex in the play fighting of rats
| Autor: | Margaret L. Forgie, Sergio M. Pellis, Heather C. Bell, Bryan Kolb, David R. McCaffrey |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Dissociation (neuropsychology) Sterilization Tubal Central nervous system Video Recording Prefrontal Cortex Lesion 03 medical and health sciences Behavioral Neuroscience Sex Factors 0302 clinical medicine Image Processing Computer-Assisted medicine Animals Rats Long-Evans Social Behavior 10. No inequality Prefrontal cortex Set (psychology) 030304 developmental biology Analysis of Variance 0303 health sciences Behavior Animal Age Factors Play and Playthings Rats Aggression medicine.anatomical_structure Animals Newborn Female Orbitofrontal cortex medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery Cognitive psychology Neuroanatomy Motor cortex |
| Zdroj: | Behavioral Neuroscience. 123:1158-1168 |
| ISSN: | 1939-0084 0735-7044 |
| Popis: | Although decorticated rats are able to engage in play, their play is abnormal in three ways. First, decorticates do not display the normal, age-related shifts in defensive strategies during development. Second, decorticates do not modify their defensive tactics in response to the social identity of their partners. Third, decorticates display a global shift in defensive tactics from more complex to less complex strategies. It has been shown that lesions of the motor cortex (MC) selectively produce the abnormal developmental effects on play, and that lesions of the orbitofrontal cortex (OFC) selectively produce the deficits in behavioral discrimination between social partners. In the current set of experiments, we demonstrate that lesions of the medial prefrontal cortex (mPFC) produce the shift from more complex to less complex defensive tactics, while leaving intact the age-related and partner-related modulation of defensive strategies. Thus, we have evidence for a triple dissociation of function between the MC, the OFC, and the mPFC with respect to social play behavior. |
| Databáze: | OpenAIRE |
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