The Effect of Intravesical Mitomycin C on Recurrence of Newly Diagnosed Superficial Bladder Cancer: A Further Report with 7 Years of Followup
| Autor: | K.M. Grigor, D.A. Tolley, G. Lallemand, Mahesh K. B. Parmar |
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| Rok vydání: | 1996 |
| Předmět: | |
| Zdroj: | Journal of Urology. 155:1233-1238 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(01)66226-8 |
| Popis: | Purpose: We determined the role, if any, of 1 and 5 instillations of intravesical mitomycin C in the treatment of newly diagnosed superficial bladder cancer.Materials and Methods: A multicenter randomized clinical trial was done involving 502 patients with newly diagnosed superficial bladder cancer. After complete transurethral resection patients were randomized into 1 of 3 treatment arms: no further treatment, 1 instillation of mitomycin C at resection and 1 instillation at resection and at 3-month intervals for 1 year (total 5 instillations). The dose of mitomycin C used was 40 mg./40 ml. water. End points were interval to first superficial recurrence, recurrence rate (defined as the number of positive cystoscopies per year) and progression-free interval rate (progression defined as the development of muscle invasive or metastatic disease, or death from bladder cancer).Results: After a median followup of 7 years 1 and 5 instillations of mitomycin C resulted in decreased recurrence rates and incr... |
| Databáze: | OpenAIRE |
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