Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients
| Autor: | Tipu Z. Aziz, Alexander L. Green, Huichun Luo, Yongzhi Huang, Shouyan Wang, Xiao Xiao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cognitive Neuroscience
Dynamic neural state Computer applications to medicine. Medical informatics R858-859.7 Sensory system Local field potential LFP local field potential Periaqueductal gray PAG/PVG periventricular/periaqueductal gray Periventricular/periaqueductal gray Sensation medicine Humans Periaqueductal Gray Radiology Nuclear Medicine and imaging RC346-429 VAS visual analog scale ComputingMethodologies_COMPUTERGRAPHICS Pain components Local network Chronic pain Regular Article Pain Perception Neurophysiology medicine.disease Neurology MPQ the McGill pain questionnaire Neural oscillation Neuropathic pain Neuralgia Neurology. Diseases of the nervous system Neurology (clinical) Psychology Neuroscience DBS deep brain stimulation |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 32, Iss, Pp 102876-(2021) |
| ISSN: | 2213-1582 |
| Popis: | Graphical abstract Highlights • The PAG/PVG carries out its biology function by oscillatory network. • Three distinct local networks of oscillations involved in pain perception, sensory and affective. • The delta oscillation is a key hub for coding pain perception. • The high-gamma oscillation is a key hub for coding sensory pain. The periventricular/periaqueductal gray (PAG/PVG) is critical for pain perception and is associated with the emotional feelings caused by pain. However, the electrophysiological characteristics of the PAG/PVG have been little investigated in humans with chronic pain. The present study analyzed the oscillatory characteristics of local field potentials (LFPs) in the PAG/PVG of eighteen neuropathic pain patients. Power spectrum analysis and neural state analysis were applied to the PAG/PVG LFPs. Neural state analysis is based on a dynamic neural state identification approach and discriminates the LFPs into different neural states, including a single neural state based on one oscillation and a combinational neural state based on two paired oscillations. The durations and occurrence rates were used to quantify the dynamic features of the neural state. The results show that the combined neural state forms three local networks based on neural oscillations that are responsible for the perceptive, sensory, and affective components of pain. The first network is formed by the interaction of the delta oscillation with other oscillations and is responsible for the coding of pain perception. The second network is responsible for the coding of sensory pain information, uses high gamma as the main node, and is widely connected with other neural oscillations. The third network is responsible for the coding of affective pain information, and beta oscillations play an important role in it. This study suggested that the combination of two neural oscillations in the PAG/PVG is essential for encoding perceptive, sensory, and affective measures of pain. |
| Databáze: | OpenAIRE |
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