Optimal single-dose epidural neostigmine for postoperative analgesia after partial hepatectomy
| Autor: | Qiao Sheng Zhong, Sheng Jin Ge, Zhang Gang Xue, Bei Wang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Injections Epidural Partial hepatectomy Fentanyl Young Adult medicine Hepatectomy Humans Pharmacology (medical) Patient controlled epidural analgesia optimal dose Pharmacology Bupivacaine Analgesics Skin incision Dose-Response Relationship Drug business.industry neostigmine Analgesia Patient-Controlled postoperative analgesia Middle Aged Surgery Neostigmine Analgesia Epidural Dixon's up-and-down method Epidural catheter patient controlled epidural analgesia Anesthesia Epidural block Female business medicine.drug Research Article |
| Zdroj: | Indian Journal of Pharmacology |
| ISSN: | 1998-3751 |
| Popis: | Objective: Neostigmine can produce analgesia by acting on the spinal cord. This study was to determine the optimal single-dose of epidural neostigmine for postoperative analgesia after partial hepatectomy. Patients and Methods: Twenty-six patients undergoing elective partial hepatectomy under general anesthesia combined with epidural block were studied. The dose of epidural neostigmine was determined using Dixon's up-and-down method, starting from neostigmine 100 μg with an interval of 25 μg. Thirty minutes after skin incision, a predetermined dose of neostigmine was injected via the epidural catheter. Each patient received 0.125% bupivacaine and fentanyl 2 μg/ml for patient controlled epidural analgesia (PCEA) after the operation. Assessment of analgesia quality was performed at 8 h and 24 h after the operation. Results : The ED 50 of epidural neostigmine in combination with PCEA for satisfactory analgesia was 226.78 ± 33.20 μg. Probit analysis showed that the ED 50 and ED 95 of epidural neostigmine were 228.63 μg (95% CI = 197.95-299.77 μg) and 300.12 μg (95% CI = 259.44-741.65 μg), respectively. Conclusion: The ED 50 and ED 95 of epidural neostigmine in combination with PCEA for satisfactory analgesia after partial hepatectomy were 228.63 μg (95% CI = 197.95-299.77 μg) and 300.12 μg (95% CI = 259.44-741.65 μg). |
| Databáze: | OpenAIRE |
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