Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank
| ISSN: | 1938-3207 |
|---|---|
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1453a9ee809ac207d36efa9a31640953 https://pubmed.ncbi.nlm.nih.gov/18614746 |
| Rights: | OPEN |
| Přírůstkové číslo: | edsair.doi.dedup.....1453a9ee809ac207d36efa9a31640953 |
| Autor: | Lorenzo D. Botto, J. David Erickson, Karen K. Steinberg, Deborah Koontz, Christopher L. Sanders, Quan He Yang, Jan M. Friedman, Stanimila Nikolova, Margaret Gallagher |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Homocysteine National Health and Nutrition Examination Survey Genotype Population Medicine (miscellaneous) Cystathionine beta-Synthase chemistry.chemical_compound Folic Acid Nutrigenomics Gene interaction Internal medicine medicine Ethnicity Prevalence Humans Carbon-Nitrogen Ligases education Genetics education.field_of_study Nutrition and Dietetics Polymorphism Genetic biology business.industry Genetic Variation (Methionine synthase) reductase Nutrition Surveys MTRR United States Ferredoxin-NADP Reductase Endocrinology chemistry Methylenetetrahydrofolate reductase Food Fortified biology.protein business |
| Zdroj: | The American journal of clinical nutrition. 88(1) |
| ISSN: | 1938-3207 |
| Popis: | Background Abnormalities of folate and homocysteine metabolism are associated with a number of pediatric and adult disorders. Folate intake and genetic polymorphisms encoding folate-metabolizing enzymes influence blood folate and homocysteine concentrations, but the effects and interactions of these factors have not been studied on a population-wide basis. Objective The objective was to assess the prevalence of these genetic polymorphisms and their relation to serum folate and homocysteine concentrations. Design DNA samples from 6793 participants in the third National Health and Nutrition Examination Survey (NHANES III) during 1991-1994 were genotyped for polymorphisms of genes coding for folate pathway enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C, methionine synthase reductase (MTRR) 66A-->G, and cystathionine-beta-synthase 844ins68. The influence of these genetic variants on serum folate and homocysteine concentrations was analyzed by age, sex, and folate intake in 3 race-ethnicity groups. Results For all race-ethnicity groups, serum folate and homocysteine concentrations were significantly related to the MTHFR 677C-->T genotype but not to the other polymorphisms. Persons with the MTHFR 677 TT genotype had a 22.1% (95% CI: 14.6%, 28.9%) lower serum folate and a 25.7% (95% CI: 18.6%, 33.2%) higher homocysteine concentration than did persons with the CC genotype. Moderate daily folic acid intake (mean: 150 microg/d; 95% CI: 138, 162) significantly reduced the difference in mean homocysteine concentrations between those with the MTHFR 677 CC and TT genotypes. We found a significant interaction between MTHFR 677C-->T and MTRR 66A-->G on serum homocysteine concentrations among non-Hispanic whites. Conclusions The MTHFR 677C-->T polymorphism was associated with significant differences in serum folate and homocysteine concentrations in the US population before folic acid fortification. The effect of MTHFR 677C-->T on homocysteine concentrations was reduced by moderate daily folic acid intake. |
| Databáze: | OpenAIRE |
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