The analgesia effect of duloxetine on post-operative pain via intrathecal or intraperitoneal administration
| Autor: | Yong-Hai Sun, Gui-Jun Lu, Wei Hu, Guo-Li Zhao, Jing Yang, Hong-Shi Li, Chao Zhu, Shengxi Wu, Yu-Lin Dong |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Microdialysis Serotonin Ketanserin Thiophenes Pharmacology Duloxetine Hydrochloride Rats Sprague-Dawley chemistry.chemical_compound Norepinephrine Idazoxan Medicine Duloxetine Animals Receptor Injections Spinal Analgesics Pain Postoperative business.industry General Neuroscience Chronic pain Adrenergic alpha-2 Receptor Antagonists medicine.disease chemistry Spinal Cord Hyperalgesia Anesthesia Serotonin 5-HT2 Receptor Antagonists business Reuptake inhibitor Injections Intraperitoneal Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Neuroscience letters. 568 |
| ISSN: | 1872-7972 |
| Popis: | One promising strategy to prevent the chronicity of post-operative pain (POP) is to attenuate acute POP during the early phase by efficacious medications with fewer side effects. Duloxetine, one of the serotonin (5-HT)-norepinephrine (NE) reuptake inhibitors (SNRI), is used to treat a wide range of acute and chronic pain. However, its effect on POP has not been investigated. In the present study, we investigated the anti-hypersensitivity effect of duloxetine using a rat model of POP. The possible involvement of spinal 5-HT2A and α2-noradrenergic receptors were also evaluated by using antagonists for 5-HT2A (ketanserin) or α2-noradrenergic receptors (idazoxan). Finally, with the method of in vivo microdialysis, the increase in spinal NA and 5-HT levels after intraperitoneal (i.p.) delivery of duloxetine were investigated. The results showed that intrathecal (i.t.) or i.p. delivery of duloxetine produced an anti-hyperalgesic effect in a dose-dependent manner. The anti-hypersensitivity effect of duloxetine was partly attenuated by pretreatment with ketanserin or idazoxane. Microdialysis study revealed that 5-HT and NA concentrations at the spinal dorsal horn were increased, peaking at 30min after i.p. injection of 20mg/kg duloxetine. These findings indicate that duloxetine inhibits POP by increasing spinal NA and 5-HT levels and activating spinal 5-HT2A or α2-noradrenergic receptors. |
| Databáze: | OpenAIRE |
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