Influence of Ethanol and Gender on Methylphenidate Pharmacokinetics and Pharmacodynamics
| Autor: | G C Janis, Arthur B. Straughn, R R Minhinnett, Kennerly S. Patrick, Robert Malcolm, A E Herrin, DeVane Cl, S D Yeatts, John S. Markowitz |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Metabolite medicine.medical_treatment Blood Pressure Pharmacology Article Body Temperature chemistry.chemical_compound Pharmacokinetics Heart Rate Heart rate mental disorders medicine Humans Pharmacology (medical) Drug Interactions Biotransformation Sex Characteristics Cross-Over Studies Ethanol Chemistry Central Nervous System Depressants Stereoisomerism Crossover study Bioavailability Stimulant Ethylphenidate Pharmacogenetics Area Under Curve Methylphenidate Respiratory Mechanics Central Nervous System Stimulants Female Geometric mean human activities medicine.drug |
| Popis: | This study explores the hypotheses that: (1) ethanol will interact with dl-Methylphenidate (MPH) to enantioselectively elevate plasma d-MPH, and primarily yield l-ethylphenidate as a transesterification metabolite; (2) women will exhibit lower relative bioavailability of MPH than men; and (3) sex-dependent differences in subjective effects will exist. dl-MPH HCl (0.3 mg/kg) was administered orally 30 min before ethanol, 30 min after ethanol (0.6 gm/kg), or without ethanol, in a randomized, normal subject three-way crossover study of 10 men and 10 women. Pharmacokinetic parameters were compared. Subjective effects were recorded using visual analog scales. One subject was a novel poor MPH metabolizer whose data were analyzed separately. Ethanol after or before MPH significantly (P |
| Databáze: | OpenAIRE |
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