Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A
| Autor: | C. H. Herrmann, David Beach, J. A. Scheppler, Ed Harlow, Antonio Giordano, Je-Hyuk Lee, U Deuschle, B. R. Franza |
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| Rok vydání: | 1991 |
| Předmět: |
viruses
Protamine Kinase Biology Cell Line Retinoblastoma-like protein 1 CDC2 Protein Kinase Humans Kinase activity Recombination Genetic Cyclin-dependent kinase 1 Multidisciplinary Cyclin-dependent kinase 4 Adenoviruses Human Adenovirus Early Proteins Cell Cycle Cyclin-dependent kinase 2 Cyclin-dependent kinase 3 Oncogene Proteins Viral Molecular biology Cell biology DNA-Binding Proteins Cell Transformation Neoplastic Cyclin-dependent kinase complex biology.protein Cyclin-dependent kinase 6 HeLa Cells Protein Binding |
| Zdroj: | Università degli Studi di Siena-IRIS |
| Popis: | Several cellular proteins form stable complexes with the proteins encoded by the adenovirus early region 1A (E1A) gene in extracts derived from adenovirus infected or transformed cells. Two of the cellular proteins that bind to E1A have been identified; one, a 105-kilodalton protein (pRb), is the product of the retinoblastoma gene, and the other, a 60-kilodalton protein, is a human cyclin A. Two other proteins that bind E1A have now been shown to be related to p34cdc2. This E1A complex displayed histone H1-specific kinase activity; the kinase activity was modulated during the cell division cycle, and association of pRb with E1A apparently was not required for this activity. |
| Databáze: | OpenAIRE |
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