Multiciliated Cells
| Autor: | John B. Wallingford, Eric R. Brooks |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
education.field_of_study
Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Cilium Population Biology General Biochemistry Genetics and Molecular Biology Epithelium Cell biology medicine.anatomical_structure Deuterosome Microtubule Motile cilium medicine General Agricultural and Biological Sciences education Multiciliation |
| Zdroj: | Current Biology. 24(19):R973-R982 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2014.08.047 |
| Popis: | Cilia are microtubule based cellular projections that serve a wide variety of essential functions in animal cells. Defects in cilia structure or function have recently emerged as etiological mechanisms underpinning diverse human diseases. While many eukaryotic cells possess only one or two cilia, some cells, including those of many unicellular organisms, exhibit extensive multiciliation. In vertebrates, multiciliated cells (MCCs) are a specialized population of post-mitotic cells decorated with dozens of motile cilia that beat in a polarized and synchronized fashion to drive directed fluid flow across an epithelium. Dysfunction of human MCCs is associated with diseases of the brain, airway and reproductive tracts. Despite their importance, MCCs are relatively poorly studied and we are only beginning to understand the mechanisms underlying their development and function. Here, we briefly review the general phylogeny and physiology of multiciliation and detail our current understanding of the developmental and cellular events underlying the formation, maturation, and function of MCCs in vertebrates. |
| Databáze: | OpenAIRE |
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