Mitochondria Can Cross Cell Boundaries: An Overview of the Biological Relevance, Pathophysiological Implications and Therapeutic Perspectives of Intercellular Mitochondrial Transfer
| Autor: | Daniela Valenti, Loredana Moro, Anna Atlante, Rosa Anna Vacca |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Mitochondrial DNA QH301-705.5 Cell oxidative phosphorylation Oxidative phosphorylation Review Mitochondrion Biology bioenergetics Mitochondrial Dynamics Catalysis Inorganic Chemistry intercellular mitochondria trafficking tunneling nanotubes 03 medical and health sciences 0302 clinical medicine Metabolic Diseases extracellular mitochondria Neoplasms Organelle extracellular mitovesicles medicine Animals Humans cancer immune-metabolic regulation Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Intercellular transport neurodevelopmental disorders Organic Chemistry Neurodegenerative Diseases General Medicine Computer Science Applications Cell biology mitochondria Chemistry 030104 developmental biology medicine.anatomical_structure Cell metabolism ccf-mtDNA mitochondrial transplantation 030217 neurology & neurosurgery Intracellular |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 8312, p 8312 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Mitochondria are complex intracellular organelles traditionally identified as the powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In recent decades, the growing interest in mitochondria research has revealed that these multifunctional organelles are more than just the cell powerhouses, playing many other key roles as signaling platforms that regulate cell metabolism, proliferation, death and immunological response. As key regulators, mitochondria, when dysfunctional, are involved in the pathogenesis of a wide range of metabolic, neurodegenerative, immune and neoplastic disorders. Far more recently, mitochondria attracted renewed attention from the scientific community for their ability of intercellular translocation that can involve whole mitochondria, mitochondrial genome or other mitochondrial components. The intercellular transport of mitochondria, defined as horizontal mitochondrial transfer, can occur in mammalian cells both in vitro and in vivo, and in physiological and pathological conditions. Mitochondrial transfer can provide an exogenous mitochondrial source, replenishing dysfunctional mitochondria, thereby improving mitochondrial faults or, as in in the case of tumor cells, changing their functional skills and response to chemotherapy. In this review, we will provide an overview of the state of the art of the up-to-date knowledge on intercellular trafficking of mitochondria by discussing its biological relevance, mode and mechanisms underlying the process and its involvement in different pathophysiological contexts, highlighting its therapeutic potential for diseases with mitochondrial dysfunction primarily involved in their pathogenesis. |
| Databáze: | OpenAIRE |
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