Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level
| Autor: | Joel N. Hirschhorn, Christopher J. O'Donnell, Peter W.F. Wilson, Emelia J. Benjamin, Philimon Gona, Stacy L. Musone, Amy L. Camargo, Jared A. Drake, Martin G. Larson, John F. Keaney, Sekar Kathiresan, Ramachandran S. Vasan, Daniel Levy, Chao-Yu Guo, Christopher Newton-Cheh |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Linkage disequilibrium Genotype Blood Pressure Single-nucleotide polymorphism Quantitative trait locus Polymorphism Single Nucleotide Body Mass Index Cohort Studies Quantitative Trait Heritable Sex Factors Framingham Heart Study Physiology (medical) Internal medicine Genetic variation medicine Humans SNP Genetic Predisposition to Disease Obesity Promoter Regions Genetic Alleles Aged Genetics biology business.industry Smoking C-reactive protein Age Factors Genetic Variation Middle Aged Lipids C-Reactive Protein Endocrinology Haplotypes Cardiovascular Diseases biology.protein Female Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Circulation. 113:1415-1423 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background— Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP. Methods and Results— We studied serum CRP in 3301 Framingham Heart Study (FHS) participants (mean age 61 years, 53% women). Twelve clinical covariates explained 26% of the variability in CRP level, with body mass index alone explaining 15% ( P CRP gene on CRP levels, we first constructed a dense linkage disequilibrium map for common single-nucleotide polymorphisms (SNPs) spanning the CRP locus (1 SNP every 850 bases, 26 kilobase [kb] genomic region). Thirteen CRP SNPs were genotyped in 1640 unrelated FHS participants with measured CRP levels. After adjustment for clinical covariates, 9 of 13 SNPs were associated with CRP level ( P P P =0.0002 and 0.004). Conclusions— In our community-based sample, clinical variables explained 26% of the interindividual variation in CRP, whereas a common triallelic CRP SNP contributed modestly. Studies of larger samples are warranted to assess the association of genetic variation in CRP and risk of cardiovascular disease. |
| Databáze: | OpenAIRE |
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