Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats
| Autor: | Rhiannon M. Meredith, Sabine Spijker, Mansvelder Hd, A. Jaap Timmerman, Tim S. Heistek, Danai Riga, Ioannis Kramvis, Anton N. M. Schoffelmeer, Anouk de Weger, Roel C. van der Schors, Witte J.G. Hoogendijk, Anton W. Pieneman, Johanneke E. van der Harst, Pieter van Bokhoven, Pim van Nierop, Maija Kreetta Koskinen, Yvar van Mourik, August B. Smit |
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| Přispěvatelé: | Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Molecular and Cellular Neurobiology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Integrative Neurophysiology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Brain Imaging, AIMMS, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience - Neurodegeneration, Psychiatry |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Imipramine Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Hippocampus Chondroitin ABC Lyase Hippocampal formation Inhibitory postsynaptic potential Extracellular matrix 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine SDG 3 - Good Health and Well-being Interneurons Memory Journal Article Animals Medicine Cognitive Dysfunction Rats Wistar Social Behavior CA1 Region Hippocampal Depression business.industry Perineuronal net Neural Inhibition Long-term potentiation General Medicine Extracellular Matrix 030104 developmental biology Chondroitin Sulfate Proteoglycans nervous system Chronic Disease Synapses Antidepressant business Neuroscience Stress Psychological 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Science Translational Medicine, 9(421):eaai8753. American Association for the Advancement of Science Science Translational Medicine, 9, eaai8753-eaai8753 Riga, D, Kramvis, I, Koskinen, M K, van Bokhoven, P, van der Harst, J E, Heistek, T S, Jaap Timmerman, A, van Nierop, P, van der Schors, R C, Pieneman, A W, de Weger, A, van Mourik, Y, Schoffelmeer, A N M, Mansvelder, H D, Meredith, R M, Hoogendijk, W J G, Smit, A B & Spijker, S 2017, ' Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats ', Science Translational Medicine, vol. 9, no. 421, eaai8753 . https://doi.org/10.1126/scitranslmed.aai8753 Riga, D, Kramvis, I, Koskinen, M K, Van Bokhoven, P, Van Der Harst, J E, Heistek, T S, Timmerman, A J, Van Nierop, P, Van Der Schors, R C, Pieneman, A W, De Weger, A, Van Mourik, Y, Schoffelmeer, A N M, Mansvelder, H D, Meredith, R M, Hoogendijk, W J G, Smit, A B & Spijker, S 2017, ' Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats ', Science Translational Medicine, vol. 9, no. 421, eaai8753 . https://doi.org/10.1126/scitranslmed.aai8753 Science Translational Medicine, 9, 421, pp. eaai8753-eaai8753 |
| ISSN: | 1946-6234 |
| DOI: | 10.1126/scitranslmed.aai8753 |
| Popis: | Patients with depression often suffer from cognitive impairments that contribute to disease burden. We used social defeat-induced persistent stress (SDPS) to induce a depressive-like state in rats and then studied long-lasting memory deficits in the absence of acute stressors in these animals. The SDPS rat model showed reduced short-term object location memory and maintenance of long-term potentiation (LTP) in CA1 pyramidal neurons of the dorsal hippocampus. SDPS animals displayed increased expression of synaptic chondroitin sulfate proteoglycans in the dorsal hippocampus. These effects were abrogated by a 3-week treatment with the antidepressant imipramine starting 8 weeks after the last defeat encounter. Next, we observed an increase in the number of perineuronal nets (PNNs) surrounding parvalbumin-expressing interneurons and a decrease in the frequency of inhibitory postsynaptic currents (IPSCs) in the hippocampal CA1 region in SDPS animals. In vivo breakdown of the hippocampus CA1 extracellular matrix by the enzyme chondroitinase ABC administered intracranially restored the number of PNNs, LTP maintenance, hippocampal inhibitory tone, and memory performance on the object place recognition test. Our data reveal a causal link between increased hippocampal extracellular matrix and the cognitive deficits associated with a chronic depressive-like state in rats exposed to SDPS. |
| Databáze: | OpenAIRE |
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