Oxidative cross-linking of fodrin parallels a membrane conductance increase in the mammalian lens
| Autor: | Matteo Belpoliti, George Duncan, Stefano A. Gandolfi, Giovanni Maraini, J. Tagliavini |
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| Rok vydání: | 1988 |
| Předmět: |
Oxidative phosphorylation
Biology Dithiothreitol law.invention Cellular and Molecular Neuroscience chemistry.chemical_compound law Lens Crystalline Animals Membrane conductance Cytoskeleton Diamide Membranes Microfilament Proteins Electric Conductivity Rats Inbred Strains Sensory Systems Cell biology Rats Lens (optics) stomatognathic diseases Ophthalmology Electrophysiology Membrane Cross-Linking Reagents chemistry Permeability (electromagnetism) Carrier Proteins Oxidation-Reduction |
| Zdroj: | Current eye research. 7(8) |
| ISSN: | 0271-3683 |
| Popis: | An oxidative cross-linking of the lens spectrin-like protein fodrin was induced by incubating WKY-rat lenses in the presence of the SH-reagent diamide. The oxidation of fodrin was paralleled by an increase in lens membrane conductance. The time relationship between these two events as well as the reversibility of both, achieved by incubating the lens in the presence of dithiothreitol, indicate that normal permeability characteristics of the lens membranes require the integrity of the membrane attached cytoskeleton. |
| Databáze: | OpenAIRE |
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