The Administration of Tenofovir Disoproxil Fumarate for Pregnant Japanese Women with Chronic Hepatitis B
| Autor: | Akihiro Tamori, Masaru Enomoto, Norifumi Kawada, Maito Suoh, Yuga Amano-Teranishi, Yasuko Kawasaki, Takashi Nakai, Kiyohide Kioka |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Hepatitis B virus Guanine Mother to child transmission Tenofovir Mothers Case Report 030204 cardiovascular system & hematology medicine.disease_cause Antiviral Agents 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Japan Chronic hepatitis Pregnancy Internal Medicine medicine Humans Hepatitis B e Antigens Child Adverse effect Transmission (medicine) business.industry mother-to-child transmission Infant Newborn virus diseases Prenatal Care General Medicine Viral Load medicine.disease Hbv replication Virology Infectious Disease Transmission Vertical digestive system diseases Pregnancy Complications tenofovir disoproxil fumarate Female 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.3504-19 |
| Popis: | The appropriate management of hepatitis B virus (HBV) infection during pregnancy has not been established in Japan. We herein report five HBV-infected pregnant Japanese women who received tenofovir disoproxil fumarate (TDF). Two of them had been born after the introduction of nationwide immunoprophylaxis and were vertically infected with HBV, highlighting the need to address mother-to-child transmission further. In both entecavir-experienced and nucleoside/nucleotide analog-naïve mothers, TDF suppressed HBV replication without serious adverse events. All five children were free from congenital disorders, growth impairment, and HBV infection. TDF showed safety and efficacy for pregnant woman with chronic hepatitis B and might have helped prevent mother-to-child transmission. |
| Databáze: | OpenAIRE |
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