Major depressive disorder and cardiometabolic disease risk among sub-Saharan African adults
| Autor: | Michelle A. Williams, Seblewengel Lemma, Xiao Hua Andrew Zhou, Yemane Berhane, Ann Vander Stoep, Jesse R. Fann, Bizu Gelaye |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Logistic regression Article Odds Diabetes Complications Risk Factors Internal medicine Diabetes mellitus mental disorders Diabetes Mellitus Odds Ratio Prevalence Internal Medicine medicine Humans Insulin Psychiatry Depression (differential diagnoses) Metabolic Syndrome Depressive Disorder Major business.industry General Medicine Odds ratio medicine.disease Lipids Confidence interval C-Reactive Protein Multivariate Analysis Major depressive disorder Female Ethiopia Metabolic syndrome business |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 9:183-191 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2014.05.003 |
| Popis: | Objective We sought to evaluate the extent to which major depressive disorder (MDD) is associated with cardiometabolic diseases and risk factors. Methods This was a cross-sectional epidemiologic study of 1924 employed adults in Ethiopia. Structured interview was used to collect sociodemographic data, behavioral characteristics and MDD symptoms using a validated Patient Health Questionnaire-9 (PHQ-9) depression scale. Fasting blood glucose, insulin, C-reactive protein, and lipid concentrations were measured using standard approaches. Multivariate logistic regression models were fitted to estimate odds ratios (OR) and 95% confidence intervals (95% CI). Results A total of 154 participants screened positive for MDD on PHQ-9 (8.0%; 95% CI: 6.7–9.2%). Among women, MDD was associated with more than 4-fold increased odds of diabetes (OR = 4.14; 95% CI: 1.03–16.62). Among men the association was not significant (OR = 1.12; 95% CI: 0.63–1.99). Similarly, MDD was not associated with metabolic syndrome among women (OR = 1.51; 95% CI: 0.69–3.29) and men (OR = 0.61; 95% CI: 0.28–1.34). Lastly, MDD was not associated with increased odds of systemic inflammation. Conclusion The results of our study do not provide convincing evidence that MDD is associated with cardiometabolic diseases among Ethiopian adults. Future studies need to evaluate the effect of other psychiatric disorders on cardiometabolic disease risk. |
| Databáze: | OpenAIRE |
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