Innate visual preferences and behavioral flexibility inDrosophila
| Autor: | Martyna J. Grabowska, James Steeves, Deniz Ertekin, Julius Alpay, Matthew Van De Poll, Bruno van Swinderen |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology genetic structures Physiology Neuropeptide F fungi Aquatic Science Optogenetics Stimulus (physiology) biology.organism_classification Attraction Nature versus nurture 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Insect Science Animal Science and Zoology Drosophila melanogaster Psychology Molecular Biology Neuroscience 030217 neurology & neurosurgery Ecology Evolution Behavior and Systematics |
| DOI: | 10.1101/336412 |
| Popis: | Visual decision-making in animals is influenced by innate preferences as well as experience. Interaction between hard-wired responses and changing motivational states determines whether a visual stimulus is attractive, aversive, or neutral. It is however difficult to separate the relative contribution of nature versus nurture in experimental paradigms, especially for more complex visual parameters such as the shape of objects. We used a closed-loop virtual reality paradigm for walkingDrosophilaflies to uncover innate visual preferences for the shape and size of objects, in a recursive choice scenario allowing the flies to reveal their visual preferences over time. We found thatDrosophilaflies display a robust attraction / repulsion profile for a range of objects sizes in this paradigm, and that this visual preference profile remains evident under a variety of conditions and persists into old age. We also demonstrate a level of flexibility in this behavior: innate repulsion to certain objects could be transiently overridden if these were novel, although this effect was only evident in younger flies. Finally, we show that a reward circuit in the fly brain,Drosophilaneuropeptide F (dNPF), can be recruited to guide visual decision-making. Optogenetic activation of dNPF-expressing neurons converted a visually repulsive object into a more attractive object. This suggests that dNPF activity in theDrosophilabrain guides ongoing visual choices, to override innate preferences and thereby provide a necessary level of behavioral flexibility in visual decision-making. |
| Databáze: | OpenAIRE |
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