Vitamin D prophylaxis during infancy: comparison of the long-term effects of three intermittent doses (15, 5, or 2.5 mg) on 25-hydroxyvitamin D concentrations
| Autor: | H Ben-Mekhbi, M Garabédian, N Djeghri, F Zeghoud |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Administration Oral Medicine (miscellaneous) chemistry.chemical_element Calcium Drug Administration Schedule vitamin D deficiency chemistry.chemical_compound Internal medicine medicine Vitamin D and neurology Humans Longitudinal Studies Calcifediol Cholecalciferol 25-Hydroxyvitamin D 2 Chemotherapy Nutrition and Dietetics Dose-Response Relationship Drug business.industry Infant Newborn Phosphorus Alkaline Phosphatase Vitamin D Deficiency medicine.disease Dose–response relationship Endocrinology chemistry Alkaline phosphatase business Potential toxicity |
| Zdroj: | The American Journal of Clinical Nutrition. 60:393-396 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/60.3.393 |
| Popis: | Serum 25-hydroxyvitamin D [25(OH)D], calcium, phosphorus, and alkaline phosphatase activities were measured from birth to 6-9 mo of age in 60 healthy neonates to assess the effectiveness and potential toxicity of three intermittent oral doses of cholecalciferol. Two weeks after a first dose of 15, 5, or 2.5 mg, 25(OH)D concentrations reached 307 +/- 160, 150 +/- 55, and 92 +/- 42 nmol/L, respectively. Prolonged vitamin D overload, up to 6 mo, was found in 50% of the children given 15 mg, but not in the other infants. Serum calcium transiently increased 2 wk after 15 mg but not after the lower doses. Oral doses of 2.5 mg given every 3 mo appear to provide the best protection against vitamin D deficiency and vitamin D overload in high-risk infant populations that are unsuitable for daily vitamin D supplementation. |
| Databáze: | OpenAIRE |
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