Decrease in luteinizing hormone biological activity/immunoreactivity ratio in elderly men
| Autor: | M.F. Celani, D. Cavani, V. Montanini, P. Marrama, M. Bazzani, K. Cioni, Cesare Carani, G. F. Baraghini |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Radioimmunoassay General Biochemistry Genetics and Molecular Biology Basal (phylogenetics) Mice Internal medicine medicine Animals Humans Testosterone Aged Leydig cell business.industry Obstetrics and Gynecology Leydig Cells Luteinizing Hormone Middle Aged Androgen medicine.anatomical_structure Endocrinology Ageing Biological Assay Gonadotropin Luteinizing hormone business |
| Zdroj: | Maturitas. 5(4) |
| ISSN: | 0378-5122 |
| Popis: | Basal serum concentrations of biologically active luteinizing hormone (BIO-LH), immunoreactive LH (RIA-LH) and testosterone (T), as well as the LH bioactivity/immunoreactivity (B/I) ratios were measured in 57 healthy, elderly male volunteers aged 60-94 yr. As a reference group, 53 healthy young men aged 18-49 yr were also studied. LH biological activity was assessed by an in vitro bioassay method based on testosterone production by mechanically dispersed mouse Leydig cell preparations in response to graded doses of LH. The mean BIO-LH and RIA-LH serum concentrations in the elderly men showed a significant increase (two- and three-fold, respectively, P less than 0.001, as compared with the values in the young men, whereas the mean LH B/I ratio and T values were significantly decreased (-22% and -43%, respectively, P less than 0.001). The decrease in the LH B/I ratio in elderly men led us to hypothesize that the ageing pituitary may secrete molecules of LH possessing a reduced bioactivity in relation to their immunoreactivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|