Response of hypogastric afferent fibers to bladder distention or irritation in cats
| Autor: | Haotian Cai, Natalie Pace, Jonathan M. Beckel, Zhaoxia Wang, Bing Shen, Changfeng Tai, Wenbin Guo, William C. de Groat, Jicheng Wang, Katherine Shapiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment Urinary Bladder Action Potentials medicine.disease_cause urologic and male genital diseases Article Hypogastric nerve 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience medicine Animals Neurons Afferent Saline Sensitization Afferent Pathways CATS Hypogastric Plexus business.industry Urinary Bladder Diseases Pathophysiology female genital diseases and pregnancy complications 030104 developmental biology medicine.anatomical_structure Nociception Allodynia Neurology Anesthesia Cats Female Saline Solution Irritation medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Exp Neurol |
| Popis: | The goal of this study in anesthetized cats was to identify silent hypogastric nerve (HGN) afferent fibers that do not respond to bladder distention but become responsive after chemical irritation of the bladder. The HGN was split into multiple filaments small enough for recording action potentials from single or multiple afferent fibers. The bladder was distended by infusion of either saline or 0.5% acetic acid (AA) through a urethral catheter while recording intravesical pressure. A total of 90 HGN filaments from 17 cats responded to bladder distention with saline or AA. Three types of HGN afferents were identified. The first type was non-nociceptive mechano-sensitive that responded to bladder distention at normal physiological pressures (10–40 cmH(2)O). The second type was nociceptive mechano-sensitive that only responded to high-pressure (50–80 cmH(2)O) bladder distention with saline but responded to low-pressure bladder distention after sensitization with AA. The third type was chemo-sensitive nociceptive that was silent even during high-pressure bladder distention but after sensitization with AA did respond to low-pressure bladder distention. These results indicate that HGN afferents as well as pelvic nerve afferents may play a role in bladder nociception. The HGN afferent fibers that are silent during bladder distention at normal physiological pressures but become responsive after chemical irritation are important for understanding the possible pathophysiological mechanism underlying bladder allodynia in painful bladder syndrome. |
| Databáze: | OpenAIRE |
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