Three Rare Concurrent Complications of Tertiary Hyperparathyroidism: Maxillary Brown Tumor, Uremic Leontiasis Ossea, and Hungry Bone Syndrome
| Autor: | Natalie Bransky, Neena Ramesh Iyer, Praneet Mylavarapu, Alexander Hanlin Tyan, Sophie Mestman Cannon, Ryan K. Orosco, Alan A. Moazzam, David Brain Hom |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Leontiasis ossea Case Report 030209 endocrinology & metabolism Tertiary hyperparathyroidism Subtotal Parathyroidectomy 03 medical and health sciences 0302 clinical medicine Endocrinology Uremic leontiasis ossea Teriparatide Biopsy Maxilla medicine Parathyroid adenoma medicine.diagnostic_test business.industry Brown tumor Hungry bone syndrome medicine.disease Surgery Skull medicine.anatomical_structure 030101 anatomy & morphology business medicine.drug |
| Zdroj: | Journal of Bone Metabolism |
| ISSN: | 2287-7029 2287-6375 |
| DOI: | 10.11005/jbm.2020.27.3.217 |
| Popis: | A 48-year-old woman in her 40’s with end-stage renal disease and tertiary hyperparathyroidism (HPT) presented for a rapidly progressive maxillary tumor. Initial workup was notable for elevated intact parathyroid hormone (PTH) and diffuse thickening of skull and facial bones on computed tomography, and maxillary tumor biopsy with multinucleated giant cells. She underwent subtotal parathyroidectomy (with removal of a parathyroid adenoma and 2 hyperplastic glands) and partial resection of maxillary brown tumor. The patient’s post-operative course was complicated by hungry bone syndrome, with hypocalcemia refractory to aggressive calcium repletion. Teriparatide (recombinant PTH) was utilized with rapid resolution of hypocalcemia. To our knowledge, this is the first case of maxillary brown tumor in tertiary HPT to be reported in the USA. This case also supports teriparatide as a novel therapeutic for hungry bone syndrome refractory to aggressive calcium repletion. |
| Databáze: | OpenAIRE |
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