Phytowaste as nutraceuticals in boosting public health
| Autor: | Orish Ebere Orisakwe, F.D. Sikoki, Chiara Frazzoli, C. N. Orish, B. B. Babatunde, Chinyere S. Dike, Chukwuemeka R. Nwokocha |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
biology Traditional medicine lcsh:R lcsh:Medicine lcsh:RX1-681 Proinflammatory cytokine Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Nutraceutical lcsh:Homeopathy Apoptosis Catalase Cell culture 030220 oncology & carcinogenesis biology.protein General Earth and Planetary Sciences Animal studies Wound healing 030304 developmental biology General Environmental Science |
| Zdroj: | Clinical Phytoscience, Vol 7, Iss 1, Pp 1-23 (2021) |
| ISSN: | 2199-1197 |
| Popis: | The utilization of bioactive constituent of peels and seeds provide an effective, environment friendly and inexpensive therapy for different forms of human disease, and the production, improvement and documentation of novel nutraceuticals. This review systematically presents findings and further understanding of the reported benefits and therapeutic applications of peel and seed extracts on innovative cell culture and animal studies, as well as phased clinical human trial research. The extracts of seed and peels were reported to possess high quantities of bioactive substances with antioxidative, antidiabetic, hepatorenal protective, antithyroidal, anti-inflammatory, antibacterial, cardiovascular protective, neuro-protective effects, anticancer and wound healing activities. Therapeutic activities of the bioactive substances of peel and seed extracts include elevation of Superoxide dismutase (SOD), GSH-Px, t-GPx, Catalase and GST activities, with the suppression of MDA levels, hydroperoxide generation and lipid peroxidized products, the extracts also regulate inflammatory mediators and cytokines as they are reported to suppress the secretion of inflammatory cytokines, which include; IL-1β, PGE2, TGF-β and TNF-α and induces apoptosis and cell differentiation. This review revealed the therapeutic importance and best utilization of peels and seed extracts of fruits and vegetables. |
| Databáze: | OpenAIRE |
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