Date seed oil loaded niosomes: development, optimization and anti-inflammatory effect evaluation on rats
| Autor: | Fathy I. Abd-Allah, Hossam S. El-Sawy, Noha M. Saeed, Talib Hussain, Mahmoud S. Soliman |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.drug_class Chemistry Pharmaceutical Anti-Inflammatory Agents Pharmaceutical Science 02 engineering and technology Pharmacology Administration Cutaneous 030226 pharmacology & pharmacy Anti-inflammatory 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Osteoarthritis Drug Discovery medicine Animals Edema Plant Oils Niosome Particle Size Rats Wistar Inflammation Liposome Chemistry Organic Chemistry Phoeniceae 021001 nanoscience & nanotechnology Rats Liposomes Seeds Nanoparticles 0210 nano-technology |
| Zdroj: | Drug Development and Industrial Pharmacy. 44:1185-1197 |
| ISSN: | 1520-5762 0363-9045 |
| Popis: | An optimized date seed oil (DSO) loaded niosomes was formulated.Maximize the extract anti-inflammatory efficacy and govern its release characteristics from nanoparticles for osteoarthritis prevention and treatment purposes.By using Box-Behnken Design, the effect of three formulation factors on the entrapment efficiency percentage (Y65.89%, 18.39%, and 58.27% were the measured responses of the optimized niosomes for YTo emphasize, DSO loading in niosomes revealed a significant enhancement toward inflammation alleviation, which offers a promising implement in osteoarthritis remediation and prohibition. |
| Databáze: | OpenAIRE |
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