Splenectomy Does Not Improve Long-Term Outcome After Stroke
| Autor: | Angela Shen, Dannielle Zierath, Astiana Stults, Theresa Olmstead, Kyra J. Becker |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Time Factors medicine.medical_treatment Splenectomy Inflammation Article 03 medical and health sciences 0302 clinical medicine Immune system Antigen medicine Animals Middle cerebral artery occlusion Stroke Advanced and Specialized Nursing biology business.industry medicine.disease Rats Myelin basic protein Surgery Treatment Outcome 030104 developmental biology Rats Inbred Lew Anesthesia Infarct volume biology.protein Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Stroke. 48:497-500 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background and Purpose— Immune responses to brain antigens after stroke contribute to poor outcome. We hypothesized that splenectomy would lessen the development of such responses and improve outcome. Methods— Male Lewis rats (275–350 g) underwent 2-hour middle cerebral artery occlusion immediately after splenectomy or sham splenectomy. Animals were survived to 4 weeks (672 hrs), and immune responses to myelin basic protein determined at euthanasia. Infarct volume was determined in a subset of animals euthanized at 72 hours. Behavioral outcomes were assessed to 672 hours. Results— Splenectomy was associated with worse neurological scores early after stroke, but infarct size at 72 hours was similar in both groups. Behavioral outcomes and immune responses to myelin basic protein were also similar among splenectomized and sham-operated animals 672 hours after middle cerebral artery occlusion. Conclusions— Splenectomy did not alter the immune responses to brain antigens or improve outcome after stroke. Differences between this study and other studies of splenectomy and stroke are examined. |
| Databáze: | OpenAIRE |
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