Stimulant Drug Treatment in Childhood-Onset Schizophrenia with Comorbid ADHD: An Open-Label Case Series
| Autor: | Anna L. Davidson, Judith L. Rapoport, Thomas F. Nugent, Julia W. Tossell, Susan B. Job, Marge Lenane, Peter Gochman, Nitin Gogtay, Alexandra Sporn, Deanna Greenstein |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Psychiatric Status Rating Scales medicine.medical_specialty Dextroamphetamine Adolescent Childhood-Onset Schizophrenia Comorbidity Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Pediatrics Perinatology and Child Health Schizophrenia medicine Humans Central Nervous System Stimulants Female Pharmacology (medical) Open label Stimulant drug Child Psychology Psychiatry Follow-Up Studies Retrospective Studies Clinical psychology |
| Zdroj: | Journal of Child and Adolescent Psychopharmacology. 14:448-454 |
| ISSN: | 1557-8992 1044-5463 |
| Popis: | The administration of psychostimulants to children with psychotic symptoms is controversial. This study reports the stimulant drug response of 5 children, aged 8-15 years, with childhood-onset schizophrenia (COS) and comorbid attention deficit hyperactivity disorder (ADHD). Four COS inpatients were given stimulants for comorbid ADHD after stabilization of psychosis on antipsychotic medication. A fifth COS inpatient received stimulants while still actively psychotic, despite concurrent neuroleptic treatment. Data from the 10-item Brief Conners Teachers Ratings Scale (BCTRS) were examined the week before, and the week after, stimulant addition. A paired t test, conducted using Conners Teachers data from these 4 subjects, indicated significant improvement in ADHD symptoms (p = 0.02). Data obtained from a retrospective chart review indicated no significant worsening of psychosis. The 2 subjects treated with mixed salts of dextroamphetamine sulfate and amphetamine sulfate remained on that medication at 6 months and at the 2-year follow-up. Our results suggest that ADHD comorbid with COS may be safely treated with a stimulant, once the psychosis is stabilized. A systematic investigation of this question may be warranted. |
| Databáze: | OpenAIRE |
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