Protective action of N-acetylcysteine on sperm quality in cyclophosphamide-induced testicular toxicity in male Wistar rats
| Autor: | Seyyid A Shittu, O T Kunle-Alabi, Yinusa Raji, S.T. Shittu, O O Akindele |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine sperm quality Antioxidant Cyclophosphamide medicine.medical_treatment chemotherapy 01 natural sciences Andrology Acetylcysteine 03 medical and health sciences Interstitial space 010608 biotechnology medicine Chemotherapy biology business.industry Sperm Protamine N-acetylcysteine adjunct drug 030104 developmental biology Toxicity biology.protein Original Article business medicine.drug |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 |
| DOI: | 10.5935/1518-0557.20180079 |
| Popis: | Background: Reductions in sperm quality due to free radical formation during cancer chemotherapy are well documented, hence the need for an adjunct antioxidant treatment during chemotherapy. This study was designed to investigate the effects of N-acetylcysteine on sperm quality following cyclophosphamide exposure in male Wistar rats. Methods: Twenty male Wistar rats weighing 150-170g were randomly assigned into 4 groups of five rats each, and were orally administered distilled water (Control), Cyclophosphamide (6mg/kg), N-acetylcysteine (100mg/kg) or Cyclophosphamide + N-acetylcysteine for 21 days. Sperm count, histone-protamine replacement, chromatin integrity, testicular histomorphometry and BAX Protein expression were assessed using standard procedures. The data was presented as mean ± SEM and analyzed using students' t- test. A p |
| Databáze: | OpenAIRE |
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