Iron Homeostasis in Mycobacterium tuberculosis: Mechanistic Insights into Siderophore-Mediated Iron Uptake
| Autor: | Manjula Sritharan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Siderophore Iron 030106 microbiology Siderophores Context (language use) Mycobactin Biology Microbiology Mycobacterium tuberculosis 03 medical and health sciences medicine Homeostasis Humans Tuberculosis Molecular Biology chemistry.chemical_classification medicine.diagnostic_test Lactoferrin Biological Transport biology.organism_classification Ferritin chemistry Transferrin Serum iron biology.protein Minireview |
| Zdroj: | Journal of Bacteriology. 198:2399-2409 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.00359-16 |
| Popis: | Mycobacterium tuberculosis requires iron for normal growth but faces a limitation of the metal ion due to its low solubility at biological pH and the withholding of iron by the mammalian host. The pathogen expresses the Fe 3+ -specific siderophores mycobactin and carboxymycobactin to chelate the metal ion from insoluble iron and the host proteins transferrin, lactoferrin, and ferritin. Siderophore-mediated iron uptake is essential for the survival of M. tuberculosis , as knockout mutants, which were defective in siderophore synthesis or uptake, failed to survive in low-iron medium and inside macrophages. But as excess iron is toxic due to its catalytic role in the generation of free radicals, regulation of iron uptake is necessary to maintain optimal levels of intracellular iron. The focus of this review is to present a comprehensive overview of iron homeostasis in M. tuberculosis that is discussed in the context of mycobactin biosynthesis, transport of iron across the mycobacterial cell envelope, and storage of excess iron. The clinical significance of the serum iron status and the expression of the iron-regulated protein HupB in tuberculosis (TB) patients is presented here, highlighting the potential of HupB as a marker, notably in extrapulmonary TB cases. |
| Databáze: | OpenAIRE |
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