Clinical studies on the effectiveness of prazosin HCl (Minipress tablets) in the treatment of dysuria accompanying benign prostatic hyperplasia
| Autor: | Masashi Takaiwa, S. Numazato, M. Kobayashi, S. Minato, T. Tsuzuki, M. Ohhori, S. Sakuma, M. Nagasawa, T. Yokota, Osamu Yamaguchi, Yasuo Shiraiwa, S. Matsui, M. Ohninata, H. Aoki |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Urethral Obstruction Dose Urology media_common.quotation_subject Prostatic Hyperplasia Urination medicine Dysuria Humans media_common Aged Aged 80 and over Prazosin HCL Dose-Response Relationship Drug business.industry Prazosin Hyperplasia Middle Aged Mean frequency medicine.disease Urination Disorders Surgery Discontinuation Urodynamics Blood pressure medicine.symptom business |
| Zdroj: | Urologia internationalis. 45 |
| ISSN: | 0042-1138 |
| Popis: | Prazosin HCl was administered in dosages of 1.5-4.5 mg/day for 4 weeks to 40 patients suffering from dysuria accompanying prostatic hyperplasia. Significant reductions were observed in the mean frequency of night-time and 24-hour urination. Additionally, significant improvements were recorded for the time for start of urination, time from start to finish of urination and related variables. The improvements correlated with dosage levels. Objective variables measured by urine flow rates also exhibited significant improvement. A statistically significant decrease in systolic without a decline in diastolic blood pressure was observed. Slight dizziness was observed in 1 patient and elevated laboratory test values in another, but neither warranted discontinuation of the medication; however, 1 patient did have two doses of medication held. Overall, the drug was judged beneficial to some degree in 95% of the patients. |
| Databáze: | OpenAIRE |
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