Relevance of Dementia in Atrial Fibrillation Patients within a Specific European Health Care Area
| Autor: | Moisés Rodríguez-Mañero, Alberto Ruano, José Ramón González-Juanatey, Javier García-Seara, Estrella López-Pardo, Alberto Cordero, José María García-Acuña, Carlos Peña-Gil, Pilar Mazón, Jose-Luis Martínez-Sande, Adrián Cid-Menéndez, Omar Kreidieh, Luis Valdés, María Pereira-Vázquez, José Novo Platas |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty CHA(2)DS(2)-VASc Epidemiology Comorbidity 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences Big data 0302 clinical medicine Thromboembolism Internal medicine Atrial Fibrillation Health care medicine Humans Dementia In patient Registries Prospective cohort study Stroke Aged Aged 80 and over business.industry Atrial fibrillation Prognosis medicine.disease Europe Survival Rate Cohort Propensity score matching Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | NEUROEPIDEMIOLOGY r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica INIA: Repositorio de Resultados de Investigación del INIA |
| ISSN: | 0251-5350 |
| Popis: | Introduction: Atrial fibrillation might increase the risk of dementia. We aim to test the hypothesis that dementia could reclassify the actual risk of stroke and death predicted by the CHA2DS2-VASc in patients with atrial fibrillation (AF). Methods: A prospective study performed in a specific health care area. Results: From our health care area (n = 348,985), throughout 2013, AF was codified in 7,990 (2.08%). Mean age was 76.83 ± 10.5, mean CHA2DS2-VASc = 3.5, 4,056 (50.8%) were females and 287 (3.6%) were diagnosed to have dementia. Patients with dementia were older and presented a higher rate of all the components of the CHA2DS2-VASc-expect vasculopathy. Differences in overall mortality were observed but not in stroke and haemorrhagic events. After propensity score matched analysis, dementia was independently associated with all-cause mortality. Addition of dementia to CHA2DS2-VASc reclassified 7.7 and 16.6% of the cohort with regard to thromboembolic events and death risk respectively. Conclusions: Patients with dementia presented a more adverse risk profile, with significant differences in all-cause mortality. |
| Databáze: | OpenAIRE |
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