Serum levels of 25(OH) vitamin D and immunoglobulin E in infants with bronchiolitis
| Autor: | Mohamed Mosaad Mohamed Suleiman, Sahar M. Fayed, Bahaa El Din Mohamed Hassanein, Doaa R. Soliman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Immunoglobulin E Age and sex Serum ige Pathogenesis 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine Vitamin D and neurology medicine 030212 general & internal medicine Respiratory health biology business.industry lcsh:RJ1-570 lcsh:Pediatrics 25(OH) D medicine.disease Endocrinology Bronchiolitis Immunology biology.protein IgE Negative correlation business |
| Zdroj: | Egyptian Pediatric Association Gazette, Vol 64, Iss 2, Pp 86-90 (2016) |
| ISSN: | 1110-6638 |
| DOI: | 10.1016/j.epag.2016.02.002 |
| Popis: | Vitamin D status has a great effect on respiratory health throughout the lifespan. The aim of this study The aim of this study was to estimate and find the relationship between both 25(OH) vitamin D and immunoglobulin E serum levels and bronchiolitis in infancy. Methods We quantified serum 25(OH) D and serum immunoglobulin E using (ELISA) in 50 infants with bronchiolitis and 31 healthy controls of matched age and sex. Results The mean serum 25(OH) vitamin D was significantly lower in cases than in controls; it was (12.3 ± 3.9 & 26.2 ± 10.0 ng/ml, respectively with p = 0.003). The mean serum IgE was significantly higher in cases than in controls; It was (170 ± 66 & 43.8 ± 14.2 IU/ml, respectively and p = 0.01). Serum IgE showed a non-significant negative correlation with serum 25(OH) vitamin D ( r = −0.141, p = >0.05). Conclusions Serum 25(OH) vitamin D was found in decreased quantities in infants with bronchiolitis and it was negatively correlated with serum IgE, suggesting that vitamin D may play a role in the pathogenesis of bronchiolitis. |
| Databáze: | OpenAIRE |
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