Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes
| Autor: | M.I. Senni, Mario Molmaro, Sergio Adamo, Bianca M. Zani, Fabrizio Eusebi, Clara Nervi |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Agonist
medicine.medical_specialty animal structures medicine.drug_class Biophysics Stimulation Chick Embryo Receptors Nicotinic Phosphoinositide Biology Phosphatidylinositols Biochemistry Nicotinic receptor chemistry.chemical_compound Ganglion type nicotinic receptor Structural Biology Internal medicine Genetics medicine Animals Inositol Phosphatidylinositol Receptor Molecular Biology Cells Cultured Receptor modulation Muscles acetylcholine cultured myotube nicotinic receptor phosphoinositide receptor modulation Cell Biology Acetylcholine Endocrinology chemistry Cultured myotube Alpha-4 beta-2 nicotinic receptor medicine.drug |
| Zdroj: | FEBS Letters. 190:161-164 |
| ISSN: | 0014-5793 |
| Popis: | Acetylcholine treatment of [3H]inositol pre-labelled cultured chick embryo myotubes results in the stimulation of phosphatidylinositol breakdown, as shown by the measurement of inositol-1-phosphate accumulating in the presence of lithium. The described effect is dependent on agonist concentration and incubation time, and is inhibited by tubocurarine and α-bungarotoxin. The activation of phosphatidylinositol breakdown by acetylcholine at extrajunctional nicotinic receptors is likely to be involved in the modulation of the functional activity of the receptor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text