Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects
| Autor: | Ming-Hoang Lai, Wen Chi Hou, Chen-Ling Huang, Hsing-Hsien Cheng |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Chromium
Male medicine.medical_specialty Antioxidant Thiobarbituric acid medicine.medical_treatment Type 2 diabetes medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Superoxide dismutase Placebos chemistry.chemical_compound Double-Blind Method Internal medicine medicine TBARS Humans chemistry.chemical_classification Glycated Hemoglobin biology Glutathione peroxidase Type 2 Diabetes Mellitus General Chemistry Middle Aged medicine.disease Catalase Oxidative Stress Endocrinology chemistry Diabetes Mellitus Type 2 Dietary Supplements biology.protein Female General Agricultural and Biological Sciences Oxidative stress |
| Zdroj: | Journal of agricultural and food chemistry. 52(5) |
| ISSN: | 0021-8561 |
| Popis: | To determine the effects of chromium (Cr) supplementations on oxidative stress of type 2 diabetes and euglycemic (EU) subjects, adult having HbA(1C) values of6.0% (EU), 6.8-8.5% (mildly hyperglycemic, MH), and8.5% (severely hyperglycemic, SH) were supplemented for 6 months with 1000 microg/day of Cr (as Cr yeast) or with a placebo. In the beginning, the levels of the plasma Cr in the MH and SH groups were 25-30% lower than those of the EU subjects. The values of thiobarbituric acid reactive substances (TBARS) and total antioxidative status (TAS) of the MH and SH groups were significantly higher than those of the EU ones. Following supplementations, the levels of plasma TBARS in the Cr groups of MH and SH groups were significantly decreased (the inverse was found in the EU) and showed no significant changes in the placebo group. The levels of plasma TAS in the Cr groups of EU and MH were significantly decreased (the inverse was found in the SH) and showed no significant changes in the placebo group. No significant difference was found in the antioxidant enzyme (superoxide dismutase, glutathione peroxidase, catalase) activities during supplementations. These data suggest that Cr supplementation was an effective treatment strategy to minimize increased oxidative stress in type 2 diabetes mellitus patients whose HbA(1C) level was8.5%, and the Cr in EU groups might act as a prooxidant. |
| Databáze: | OpenAIRE |
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