Low levels of protein Z are associated with HELLP syndrome and its severity
| Autor: | Tulin Firatli-Tuglular, Tayfur Toptas, Muzaffer Demir, Vedat Ugurel, Isik Kaygusuz |
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| Přispěvatelé: | Kaygusuz, Isik, Firatli-Tuglular, Tulin, Toptas, Tayfur, Ugurel, Vedat, Demir, Muzaffer |
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty HELLP Syndrome HELLP syndrome Protein Z Severity of Illness Index Preeclampsia preeclampsia chemistry.chemical_compound consumptive coagulopathy Pregnancy Internal medicine Lactate dehydrogenase medicine Humans Platelet Aspartate Aminotransferases RISK Hematology L-Lactate Dehydrogenase business.industry protein Z Platelet Count VEIN General Medicine Blood Proteins medicine.disease Hemolysis fetal demise THROMBOSIS Endocrinology chemistry Female business |
| Zdroj: | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 17(2) |
| ISSN: | 1938-2723 |
| Popis: | Protein Z (PZ) was found to be associated with pregnancy complications. There are no data implying an association between hemolysis (H), elevated liver enzymes (EL), and low platelet counts (LP) (HELLP) syndrome and changes in plasma levels of PZ. The aim of this study is to investigate whether HELLP syndrome is associated with plasma concentrations of PZ. Protein Z levels in 29 women with HELLP syndrome were compared with 29 healthy, nulliparous and 25 normal pregnant women. The median PZ levels in patients with HELLP syndrome were found to be significantly lower than those of pregnant women. No significant difference was found between HELLP and healthy groups. Protein Z levels correlated with platelet counts, lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) levels in patients with HELLP syndrome. Median PZ level was higher in partial HELLP than in complete HELLP. We calculated 1330 ng/mL as a cutoff value for PZ level to discriminate HELLP syndrome from normal pregnancy. Low PZ levels are associated with the pathobiology of HELLP syndrome. |
| Databáze: | OpenAIRE |
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