A CORRELATION BETWEEN URINARY STEROID METABOLITES AND PATHWAYS OF STEROIDOGENESIS IN HUMAN BREAST-TUMOUR TISSUE
| Autor: | J.B. Adams, M.S.F. Wong |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Adult
medicine.medical_specialty Urinary system Population Dehydroepiandrosterone Breast Neoplasms Urine Biology Breast cancer Internal medicine medicine Carcinoma Humans education Aged education.field_of_study Estriol Cancer Adrenalectomy General Medicine Middle Aged medicine.disease 17-Ketosteroids Endocrinology Chemistry Clinical Female Steroids Breast disease Menopause Adenofibroma Androstanes |
| Zdroj: | The Lancet. 292:1163-1166 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(68)91640-1 |
| Popis: | The ability of breast-carcinoma tissue to participate in steroid-hormone synthesis in vitro, led to the determination of certain steroid-hormone metabolites in urine. In particular 16-hydroxylated derivatives of dehydroepiandrosterone (D.H.E.A.) were selected since possession of a steroid 16α hydroxylase was a characteristic feature of breast-carcinoma tissue. Androst-5-ene-3β, 16α, 17β-triol (α-triol) was found to be elevated in premenopausal women with breast cancer or benign breast disease and, when expressed as a ratio to dehydroepiandrosterone or to the sum of D.H.E.A., 16α-hydroxy-D.H.E.A., and 16-oxoandrostenediol, the above group gave results highly significantly different from controls. A castrated, adrenalectomised woman with carcinoma of the breast was found to excrete D.H.E.A., 16α-hydroxy-D.H.E.A., and 16-oxoandrostenediol in her urine. After perfusion of D.H.E.A. sulphate high levels of the above compounds, together with α-triol, were found in the urine. |
| Databáze: | OpenAIRE |
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