Preclinical research on stress, memory, and the brain in the development of pharmacotherapy for depression
| Autor: | Adam M. Campbell, David M. Diamond, Collin R. Park, Rose-Marie Vouimba |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Thiazepines
Long-Term Potentiation Effects of stress on memory Antidepressive Agents Tricyclic Amygdala Memory Stress Physiological medicine Humans Pharmacology (medical) Chronic stress Tianeptine Prefrontal cortex Biological Psychiatry Pharmacology Depressive Disorder Working memory Long-term memory Brain Antidepressive Agents Psychiatry and Mental health medicine.anatomical_structure nervous system Neurology Memory consolidation Neurology (clinical) Psychology Cognitive psychology medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 14:S491-S495 |
| ISSN: | 0924-977X |
| Popis: | We have reviewed two areas of research on stress, memory, and synaptic plasticity which may be relevant toward understanding the neurobiology of major depressive disorder (MDD). First, we have presented the view that the hippocampus (HC) and prefrontal cortex (PFC) function jointly as a memory system which enables multitask processing (working memory) and consolidation of contextual information. The amygdala, by contrast, is necessary for the consolidation of emotional memories. Cognitive and neurophysiological studies have shown that HC-PFC processing is impaired, and amygdaloid processing is enhanced, by stress and in anxiety and mood disorders, including MDD. Second, we have reviewed research on the behavioral and neurophysiological actions of tianeptine, an antidepressant that is known to block the adverse effects of chronic stress on hippocampal morphology. Recent work has shown that acute tianeptine enhances cognitive and electrophysiological measures of HC-PFC functioning without interfering with the emotion-induced enhancement of amygdaloid functioning in rodents. We conclude with a synthesis of the preclinical and clinical literature on stress, memory, and tianeptine with the proposal that tianeptine should enhance HC-PFC memory-related processing in people under stress. |
| Databáze: | OpenAIRE |
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