Foetal exposure to heavy metals and risk of atopic diseases in early childhood
Autor: | Lucile Sesé, Giuliana Ferrante, Lucia Calciano, Guy Huel, Raphael Lhote, Boris Dessimond, Ramen Munir Baloch, Isabella Annesi-Maesano, Giancarlo Pesce, Munawar Hussain Soomro, Cara Nichole Maesano, Martine Guinot, Benoit Travert, Julie Prud'homme |
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Přispěvatelé: | Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Università degli studi di Verona = University of Verona (UNIVR), Università degli studi di Palermo - University of Palermo, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gestionnaire, Hal Sorbonne Université, Pesce G, Sesé L, Calciano L, Travert B, Dessimond B, Maesano CN, Ferrante G, Huel G, Prud'homme J, Guinot M, Soomro MH, Baloch RM, Lhote R, Annesi-Maesano I, Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Verona (UNIVR), Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
atopic dermatiti Allergy cadmium [SDV]Life Sciences [q-bio] Immunology Physiology 010501 environmental sciences 01 natural sciences Dermatitis Atopic 03 medical and health sciences 0302 clinical medicine Settore MED/38 - Pediatria Generale E Specialistica Food allergy Pregnancy Metals Heavy medicine Immunology and Allergy Humans 0105 earth and related environmental sciences Asthma food allergy lead atopic dermatitis business.industry Incidence (epidemiology) Hazard ratio Infant Atopic dermatitis asthma medicine.disease allergy Rhinitis Allergic 3. Good health in utero exposure [SDV] Life Sciences [q-bio] 030228 respiratory system In utero Cord blood Child Preschool Pediatrics Perinatology and Child Health manganese Female eczema business Food Hypersensitivity |
Zdroj: | Pediatric Allergy and Immunology Pediatric Allergy and Immunology, Wiley, 2020, ⟨10.1111/pai.13397⟩ |
ISSN: | 0905-6157 1399-3038 |
Popis: | International audience; Background: Accumulating evidence suggests that in utero exposures can influence the development of the immune system and thus contribute to disease development. Studies investigating the association between prenatal exposures to heavy metals and atopic diseases, however, are scarce.Methods: Children from the EDEN birth cohort were prospectively followed up using parental questionnaires with validated questions on asthma, allergic rhinitis, eczema, and food allergy symptoms. The questionnaires were administered every 4 months during the children's first year, and then every year until the age of 5, with a final survey at the age of 8. Serum concentrations of lead (Pb), cadmium (Cd), and manganese (Mn) were assessed in maternal blood samples collected during mid-pregnancy and in cord blood of 651 mother-children pairs. Hazard ratios (HR) for the incidence of each atopic disease in relation to the exposure to metals were calculated using Cox proportional hazard models.Results: Levels of Cd in cord blood were associated with greater risk of asthma (hazard ratio [95% confidence interval] for upper vs lower quartile: 1.81 [1.00-3.29]), eczema (1.60 [1.09-2.35]), and food allergy (3.17 [1.36-7.38]), while Mn levels in maternal serum were associated with eczema (1.55 [1.05-2.28]). These associations were similar in males and females and were confirmed using log concentrations of metals as exposures.Conclusions: Our results support the hypothesis that fetal exposure to heavy metals may affect the development of asthma, eczema, and food allergy in childhood and suggest that timing of exposure in utero may have a role in these associations. |
Databáze: | OpenAIRE |
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