Роль генетических исследований в диагностике заболеваний височно-нижнечелюстного сустава
| Autor: | К. А. Semenov, О. V. Denga, V. N. Gorokhivsky |
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| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Клінічна хірургія, Vol 85, Iss 5, Pp 51-54 (2018) |
| ISSN: | 2522-1396 0023-2130 |
| Popis: | Objective. In accordance to the genetic investigation results and their numerical value to confirm clinical diagnoses in patients for further adjustment of the treatment-prophylactic plan. Маterials and methods. In the investigation 10 patients took part: 5 women and 5 men, ageing 25 - 50 yrs old. Analysis was conducted in laboratory of molecular– genetic investigations – Ltd «Germedtech», City of Odessa. The Dellaport’s method was applied for isolation and purification of deoxyribonucleic acid from buccal cells. Results. Basing on results of the genes GSTM1, CoL2A1, MMP1, ER, IL1B, TNF analysis, taking part in metabolism of the joint osteo–cartilaginous tissue, a genetic risk of the diseases of the temporo-mandibular joint development was determined. Conclusion. Basing on genetic investigation, concerning certain quantity of genetic markers and their analysis, clinical diagnoses were clarified and confirmed. Certain quantity of genetic markers and their numerical values permit to prognosticate the pathological process course, to conduct treatment and prophylactic measures and to elaborate individual protocol of treatment on this background in patients, suffering diseases of temporo-mandibular joint. |
| Databáze: | OpenAIRE |
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