Sinoporphyrin sodium, a novel sensitizer for photodynamic and sonodynamic therapy
| Autor: | Cheng Wang, Jian-Chun Wang, Wei-Xin Li, Bo Yuan, Han-Qing Liu, Ya-Wen An, Zhiwen Li, Hong-Tao Jin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
material advances Chemistry medicine.medical_treatment Sonodynamic therapy Photodynamic therapy 02 engineering and technology General Chemistry safety and metabolism 021001 nanoscience & nanotechnology Combinatorial chemistry 03 medical and health sciences photodynamic therapy Materials Chemistry medicine Sinoporphyrin sodium sonodynamic therapy 0210 nano-technology sinoporphyrin sodium QD1-999 030304 developmental biology |
| Zdroj: | Open Chemistry, Vol 18, Iss 1, Pp 691-701 (2020) |
| ISSN: | 2391-5420 |
| Popis: | Sinoporphyrin sodium (DVDMS) is a novel sensitizer discovered by Professor Fang Qi-Cheng and widely used in photodynamic (PDT) and sonodynamic therapy (SDT). We searched databases including PubMed, Web of Science, CNKI, etc. for system review of its progress. We found that, both DVDMS-PDT and -SDT had been proven effective for inhibiting tumor growth and mechanisms involved reactive oxygen species, autophagy, and mitochondrial apoptosis pathways. Material advances enhanced antitumor effects and expanded its application. The safety of DVDMS in animals was evaluated, and metabolic parameters were uncovered. Additionally, DVDMS-PDT also exhibited therapeutic effects on non-neoplastic diseases like psoriasis and bacterial infections. Two phase I clinical trials of DVDMS have been documented, but recruitments had still not been completed. In conclusion, DVDMS is a promising sensitizer for both PDT and SDT; however, there are some shortcomings in previous studies like inconsistent treatment parameters, which need systematic assessments in future. Moreover, more mechanisms such as the role of autophagy need to be discovered. Further evidence of the safety and effectiveness of new materials are needed, and the application in non-neoplastic diseases like actinic keratosis and fungal infection deserves further development. Above all, promoting its clinical applications is the most important goal. |
| Databáze: | OpenAIRE |
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