Comparing the Diagnostic Accuracy of RTE and SWE in Differentiating Malignant Thyroid Nodules from Benign Ones: a Meta-Analysis
| Autor: | Yan Jiang, Lingji Guo, Wuguo Tian, Jie Yan, Shu Zhang, Donglin Luo, Bo Gao, Shuai Hao, Xiaohua Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Thyroid nodules
Real-time elastography medicine.medical_specialty Physiology Diagnostico diferencial Diagnostic accuracy Sensitivity and Specificity lcsh:Physiology 030218 nuclear medicine & medical imaging Diagnosis Differential lcsh:Biochemistry 03 medical and health sciences Sensitivity 0302 clinical medicine Ethnicity medicine Humans lcsh:QD415-436 Thyroid Nodule Real time elastography Shear wave elastography lcsh:QP1-981 medicine.diagnostic_test business.industry medicine.disease Meta-analysis ROC Curve 030220 oncology & carcinogenesis Specificity Elasticity Imaging Techniques Radiology Elastography Malignant thyroid nodules Nuclear medicine business Publication Bias |
| Zdroj: | Cellular Physiology and Biochemistry, Vol 39, Iss 6, Pp 2451-2463 (2016) |
| ISSN: | 1421-9778 1015-8987 |
| DOI: | 10.1159/000452513 |
| Popis: | Background: Approximately 10-20 million Americans have been clinically diagnosed with thyroid nodules. Shear wave elastography (SWE) and real-time elastography (RTE) are two primary forms of elastography for identifying the status of thyroid nodules. The aim of this study is to assess the performance of RTE and SWE in identifying malignant thyroid nodules. Methods: Relevant articles were systematically retrieved from PubMed, Embase and Cochrane Library. In order to evaluate the overall diagnostic accuracy, we have considered pooled sensitivity (SEN), specificity (SPE), area under the curve (AUC) and partial AUC with corresponding 95% confidence intervals (95%CIs). Stratified analyses by ethnicity (Caucasian, Asian), the number of malignant nodules (> 50, < 50), score system (elasticity scores: ES and strain ration: SR) and ES (> 4, < 4) were performed to explore potential sources of heterogeneity. All statistical tests were performed using the R 3.2.1 software package. Results: We analyzed 80 trials from 71 studies with 16,624 subjects (12,348 for SWE, 4,276 for RTE). The pooled results suggested that RTE is more accurate than SWE in diagnosing malignant cases (RTE: SEN= 0.829, 95%CI = 0.799-0.855, SPE = 0.828, 95%CI = 0.789-0.862, AUC = 0.889; SWE: SEN = 0.784, 95%CI = 0.732-0.828, SPE = 0.824, 95%CI = 0.766-0.871, AUC = 0.859). No significant difference was found in the subgroup analyses. Conclusion: Our findings revealed that RTE is superior to SWE in differentiating malignant and benign thyroid nodules. Nevertheless, more studies focusing on the diagnostic accuracy of RTE and SWE during different stages of thyroid nodules development should be carried out in the future. |
| Databáze: | OpenAIRE |
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