Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse
| Autor: | S. Malcolm, E.A. Nera, Roger Mongeau, E. Lok, David B. Clayson, F. W. Scott |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
medicine.medical_specialty Mitotic index Cell division Ratón Urinary Bladder Calorie restriction Crypt Mammary gland Biology Mice Esophagus Mammary Glands Animal Dermis Internal medicine Mitotic Index medicine Animals Skin Analysis of Variance Cell growth Body Weight Animal Feed Diet Intestines medicine.anatomical_structure Endocrinology Oncology Animal Nutritional Physiological Phenomena Female Cell Division |
| Zdroj: | Cancer Letters. 51:67-73 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(90)90232-m |
| Popis: | Two experiments have been conducted to determine the effects of calorie restriction on cellular proliferation in female mouse tissues. In the first experiment, 25% calorie restriction led to a decrease in cellular proliferation, measured by the [3H]thymidine labeling index, in each of the 7 tissues examined. The duct lining cells of the mammary gland were the most affected. This conclusion was confirmed in the second experiment in which levels of 0, 10, 20, 30 and 40% calorie restriction were employed. The difference in response of the duct cells of the mammary gland and the crypt cells of the colo-rectum is discussed in light of the opinion that the formation of cancer of these tissues in humans may be markedly affected by diet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|