Rate of non-invasive follicular thyroid neoplasms with papillary-like nuclear features depends on pathologist’s criteria: a multicentre retrospective Southern European study with prolonged follow-up
| Autor: | Pilar Fernández-Seara, Carles Zafon, Rosa Maria Bella, Emma Anda, Victoria Alcázar, Concha Blanco, Hernán Quiceno, Montserrat Chao, Isabel Mancha, Susana Lopez-Agulló, Carmela Iglesias, Ángel Castaño, Miguel Paja, Saioa Echeverría, Inés Gómez de la Riva, Garcilaso Riesco-Eizaguirre, Nancy M. Sánchez-Gómez, Ismael Capel, Telma Meizoso, María Victoria Ortega, Jose J. Paricio, Gemma Rodríguez-Carnero, Antonia Pérez-Lázaro, Luis García-Pascual, José Cameselle-Teijeiro, Clarisa González, Javier Maravall, Javier Sanz, Antónia Povoa, Esther Roselló, Pascual Meseguer, Aitziber Ugalde |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
endocrine system Thyroid neoplasm Pathology medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism medicine.disease_cause Pathologist Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Endocrinology Cytology Adenocarcinoma Follicular Humans Medicine Thyroid Neoplasms Pathological Retrospective Studies business.industry NIFTP WDT-UMP Thyroid Retrospective cohort study humanities Pathologists NIFTP Papillary thyroid carcinoma Pathologist Retrospective study Thyroid neoplasm WDT-UMP Retrospective study medicine.anatomical_structure Papillary thyroid carcinoma 030220 oncology & carcinogenesis Cohort Thyroglobulin Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | ENDOCRINE r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname r-FISABIO. Repositorio Institucional de Producción Científica |
| ISSN: | 1559-0100 1355-008X |
| Popis: | Purpose To determine the rate of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in a multi-institutional series from the Iberian Peninsula and describing this NIFTP cohort. Methods Retrospective study of papillary thyroid carcinoma (PTC) or well-differentiated tumours of uncertain malignant potential (WDT-UMP) diagnosed between 2005 and 2015 and measuring >= 5 mm in adult patients from 17 hospitals. Pathological reports were reviewed to determine the cases that fulfil the original criteria of NIFTP and histology was reassessed. Rates were correlated with the number of PTC and its follicular variant (FVPTC) of each institution. Demographic data, histology, management, and follow-up of the reclassified NIFTP cohort were recorded. Results A total of 182 cases with NIFTP criteria were identified: 174/3372 PTC (rate: 5.2%; range: 0-12.1%) and 8/19 WDT-UMP (42.1%). NIFTP rate showed linear correlation with total PTC (p: 0.03) and FVPTC (p: 0.007) identified at each centre. Ultrasound findings were non-suspicious in 60.1%. Fine-needle cytology or core biopsy diagnoses were undetermined in 49.7%. Most patients were treated with total thyroidectomy. No case had nodal disease. Among patients with total thyroidectomy, 89.7% had an excellent response evaluated 1 year after surgery. There were no structural persistence or relapses. Five patients showed residual thyroglobulin after 90 months of mean follow-up. Conclusions NIFTP rate is low but highly variable in neighbouring institutions of the Iberian Peninsula. This study suggests pathologist's interpretation of nuclear alterations as the main cause of these differences. Patients disclosed an excellent outcome, even without using the strictest criteria. |
| Databáze: | OpenAIRE |
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