Polydatin attenuates chronic alcohol consumption-induced cardiomyopathy through a SIRT6-dependent mechanism

Autor:	Li-Ming Yu, Xue Dong, Ning Li, Hui Jiang, Ji-Kai Zhao, Yin-Li Xu, Deng-Yue Xu, Xiao-Dong Xue, Zi-Jun Zhou, Yu-Ting Huang, Qiu-Sheng Zhao, Zhi-Shang Wang, Zong-Tao Yin, Hui-Shan Wang
Rok vydání:	2022
Předmět:	Alcoholism Mice Alcohol Drinking Ethanol Glucosides Cardiomyopathy Alcoholic Stilbenes Animals Sirtuins General Medicine AMP-Activated Protein Kinases Food Science
Zdroj:	Food & Function. 13:7302-7319
ISSN:	2042-650X 2042-6496
DOI:	10.1039/d2fo00966h
Popis:	Polydatin has attracted much attention as a potential cardioprotective agent against ischemic heart disease and diabetic cardiomyopathy. However, the effect and mechanism of polydatin supplementation on alcoholic cardiomyopathy (ACM) are still unknown. This study aimed to determine the therapeutic effect of polydatin against ACM and to explore the molecular mechanisms with a focus on SIRT6-AMP-activated protein kinase (AMPK) signaling and mitochondrial function. The ACM model was established by feeding C57/BL6 mice with an ethanol Lieber-DeCarli diet for 12 weeks. The mice received polydatin (20 mg kg
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142862270f11d86c90179f81cc7586b2 https://doi.org/10.1039/d2fo00966h Zobrazit plný text záznamu