Massive osteolysis in a girl with agenesis of thyroid C cells
| Autor: | Kristina Potočki, Zlatko Giljević, Mirko Koršić, Dražen Jelašić, Izet Aganović |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pathology Osteolysis Bone disease Thyroid Gland Bone resorption Pelvis Fatal Outcome Humans Medicine Radiology Nuclear Medicine and imaging Bone Resorption Pressure Ulcer business.industry Thyroid medicine.disease Radiography medicine.anatomical_structure Calcitonin Child Preschool Agenesis Female Osteolysis Essential Histopathology business Hormone |
| Zdroj: | Skeletal Radiology. 27:525-528 |
| ISSN: | 1432-2161 0364-2348 |
| DOI: | 10.1007/s002560050433 |
| Popis: | A rare case of massive osteolysis affecting the pelvis of a young girl is presented. The clinical, radiographic, and histopathological features are described in detail. Septicemia complicated the clinical course and the patient eventually died. Histopathological examination of the pelvic lesion revealed massive osteolysis characterized by prominent osteoclastic activity with extensive bone resorption. A thorough post-mortem histological examination of the thyroid gland showed no C cells. This is an interesting observation, since it is known that thyroid C cells are the primary source of calcitonin. Since the main biological effect of calcitonin is to inhibit osteoclastic bone resorption, there is a possibility that massive osteolysis in our case could have been related to the lack of this hormone. There is a clear need for further investigation regarding the role of thyroid C cells and calcitonin in this puzzling disease. |
| Databáze: | OpenAIRE |
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