Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus
| Autor: | Kalynn M. Schulz, Jennifer N. Pearson, Manisha Patel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Morris water navigation task Status epilepticus Motor Activity Neuropsychological Tests Epileptogenesis Spatial memory Article Temporal lobe Rats Sprague-Dawley Random Allocation Status Epilepticus medicine Animals Maze Learning Spatial Memory Recognition memory Kainic Acid Long-term memory Pilocarpine Recognition Psychology Cognition Disease Models Animal Memory Short-Term Neurology Exploratory Behavior Neurology (clinical) medicine.symptom Psychology Neuroscience |
| Zdroj: | Epilepsy Research. 108:1032-1040 |
| ISSN: | 0920-1211 |
| DOI: | 10.1016/j.eplepsyres.2014.04.003 |
| Popis: | Cognitive impairment is a common comorbidity in patients with Temporal Lobe Epilepsy (TLE). Learning and memory impairments can be recapitulated in animal models, particularly those using chemoconvulsants. Here, we used two relatively low-stress behavioral paradigms, the novel object recognition task (NOR) and a spatial variation, the novel placement recognition task (NPR) to reveal deficits in short and long term memory, in both kainic acid (KA) and pilocarpine (Pilo) treated animals. We found that both KA- and Pilo-induced significant deficits in long term recognition memory but not short term recognition memory. Additionally, KA significantly impaired spatial memory as detected by both NPR and Morris water maze. These deficits were present one week after SE. The characterization of memory performance of two chemoconvulsant- models, one of which is considered a surrogate organophosphate, provides an avenue for which targeted cognitive therapeutics can be tested. |
| Databáze: | OpenAIRE |
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