Benzoquinones Inhibit the Expression of Inducible Nitric Oxide Synthase Gene

Autor:	Keiko Kitajima, Shiroh Futaki, Noriko Nakamura, Mari Ueda, Yoshihisa Takaishi, Yasuyuki Tsutsumishita, Mineo Niwa
Rok vydání:	1997
Předmět:	biology Chemistry Biophysics Cell Biology Biochemistry Molecular biology Gene Expression Regulation Enzymologic Rats Nitric oxide synthase Genes Inos mrna Benzoquinones Tumor Cells Cultured biology.protein Animals RNA Messenger Nitric Oxide Synthase Neuroglia Molecular Biology Gene Inos gene
Zdroj:	Biochemical and Biophysical Research Communications. 239:367-371
ISSN:	0006-291X
Popis:	Benzoquinones inhibited the production of NO induced by LPS and γ-IFN in C6 glia cells. The mechanistic studies showed that benzoquinones inhibited the expression of iNOS mRNA through inactivation of NF κ B. Benzoquinones may be a useful candidate for the development of a drug to treat disease due to iNOS gene over-expression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14261377cf2d33ce58330aa5c173fe42 https://doi.org/10.1006/bbrc.1997.7437 Zobrazit plný text záznamu Full Text from ScienceDirect