An observational study investigating failure of primary endocrine therapy for operable breast cancer in the elderly
| Autor: | Rachel Rowell, Robert J. Thomas, Henry Cain, Siobhan Crichton |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Antineoplastic Agents Hormonal Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Humans 030212 general & internal medicine Treatment Failure Stage (cooking) Lymph node Aged Retrospective Studies Aged 80 and over business.industry Disease Controlled Endocrine therapy Retrospective cohort study medicine.disease Tamoxifen medicine.anatomical_structure England 030220 oncology & carcinogenesis Lymphatic Metastasis Secondary Outcome Measure Observational study Female Lymph Nodes business |
| Zdroj: | Breast cancer research and treatment. 167(1) |
| ISSN: | 1573-7217 |
| Popis: | Elderly patients are more likely to have oestrogen receptor positive cancers that can be treated without surgery with primary endocrine therapy (PET). Few studies have sought to identify predictors of failure of PET and so the aim of this study was to evaluate treatment failures in elderly breast cancer patients treated with PET and to determine predictors of failure. A retrospective observational study was performed on consecutive patients with ER-positive early stage breast cancer treated with PET between 2005 and 2015 in the three breast units in the North East of England. The primary outcome measure was treatment failure and secondary outcome measure was disease progression. 488 patients were included with mean follow-up 31 months (SD 23). Overall, 206 patients were still alive with their disease controlled at the end of follow-up, 219 had died with their disease controlled and 63 (12%) experienced treatment failure. Younger age [SHR 0.96 (95% CI 0.94–0.99) p 0.013], larger tumours [SHR 1.03 (1.01–1.06) p 0.015], grade 3 cancers [SHR 3.58 (1.93–6.63) p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink