The properties and reactions of decamethonium iodide and hexamethonium bromide
| Autor: | B. E. Wilde, M. B. Levy, I. E. Balaban |
|---|---|
| Rok vydání: | 1949 |
| Předmět: |
Pharmacology
Bromides Tetraethylammonium iodide Bromine Chemistry medicine.medical_treatment Decamethonium Compounds Iodine Compounds Pharmaceutical Science Decamethonium iodide chemistry.chemical_element Iodine Chloride Hexamethonium Iodine compounds chemistry.chemical_compound medicine Hexamethonium Bromide Organic chemistry Antidote medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 1(9) |
| ISSN: | 0022-3573 |
| Popis: | The work of Paton and Zaimis1 on decamethonium iodide (α:ω-hexamethyldiaminodecane diiodide, known as C.10) showed that it was a very potent substance, and that it was capable of replacing d-tubocurarine chloride in medicine. An antidote exists for decamethonium iodide in hexamethonium bromide (α:ω-hexamethyldiaminohexane dibromide, known as C.6), and owing to its pharmacological properties this substance has been suggested for use in hypertension and vascular diseases, thereby replacing tetraethylammonium iodide. Hexamethonium bromide is 10 to 20 times as active as the tetraethyl compound. In view, therefore, of the possible importance of the new drugs, it was considered desirable that an examination should be made of their physical and chemical properties. We are indebted to Mr. F. Ridgway for carrying out some of the determinations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text