Differential role for CD277 as a co-regulator of the immune signal in T and NK cells

Autor: Javier Celis-Gutierrez, Nassima Messal, Bruno Chetaille, Aude Sylvain, Emilie Mamessier, Sonia Pastor, Qian Wang, Marie-Laure Thibult, Yves Guillaume, Ivan Hirsch, Jacques A. Nunès, Guylène Firaguay, Daniel Olive
Přispěvatelé: Nunès, Jacques, Centre de Recherche en Cancérologie de Marseille (CRCM / U891 Inserm), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National du Cancer (# PL-06026 and # INCa/DHOS 2009), Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Sichuan Provincial Center for Diseases Control and Prevention, Sichuan Government, Laboratoire d'Immunologie des Tumeurs, Université de la Méditerranée - Aix-Marseille 2-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), mamessier, emilie, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
CD4-Positive T-Lymphocytes
MESH: Antigens
CD28
MESH: Protein Isoforms
Lymphocyte Activation
Interleukin 21
MESH: NK-cell
0302 clinical medicine
Chlorocebus aethiops
MESH: Up-Regulation
Protein Isoforms
Immunology and Allergy
Butyrophilin
MESH: Animals
IL-2 receptor
MESH: Antigens
CD
ComputingMilieux_MISCELLANEOUS
Cell Line
Transformed
0303 health sciences
MESH: Cytokines
Janus kinase 3
CD28
MESH: CD4-Positive T-Lymphocytes
MESH: Receptors
Antigen
T-Cell
Up-Regulation
Cell biology
cell activation
Killer Cells
Natural
MESH: COS Cells
COS Cells
Interleukin 12
Cytokines
[SDV.IMM]Life Sciences [q-bio]/Immunology
costimulatory molecules
[SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy
MESH: Natural Cytotoxicity Triggering Receptor 3
Cell activation
MESH: Killer Cells
Natural
[SDV.IMM] Life Sciences [q-bio]/Immunology
MESH: Interferon-gamma
Immunology
Receptors
Antigen
T-Cell
T cells
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biology
Interferon-gamma
03 medical and health sciences
Immune system
CD28 Antigens
[SDV.CAN] Life Sciences [q-bio]/Cancer
Antigens
CD
MESH: Cell Proliferation
Animals
Humans
MESH: Cell Line
Transformed
Antigen-presenting cell
MESH: Lymphocyte Activation
Cell Proliferation
030304 developmental biology
Natural Cytotoxicity Triggering Receptor 3
MESH: Humans
Butyrophilins
MESH: T-cell
[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy
MESH: Cercopithecus aethiops
030215 immunology
Zdroj: European Journal of Immunology
European Journal of Immunology, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩
ISSN: 0014-2980
1521-4141
DOI: 10.1002/eji.201141404
Popis: International audience; The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine production and cell proliferation, even when another co-stimulatory molecule, CD28, is engaged. These CD277-induced additive functional effects are in accordance with the detection of early T-cell activation events such as TCR-induced cell signaling being increased upon CD277 engagement. However, we found that CD277 triggering is not involved in CD16- or NKp46-induced NK cell activation. BTN3/CD277 comprises three structurally related members, BTN3A1, BTN3A2 and BTN3A3. CD277 antibodies recognize all isoforms and we describe a differential expression of BTN3 isoforms between T and NK cells that could explain differential CD277 functions between T and NK cells. Our results show that, while T cells express all BTN3/CD277 transcripts, NK cells express mostly BTN3A2, which lacks the B30.2 intracellular domain. Furthermore, NKp30-induced cytokine production is decreased by the specific engagement of BTN3A2, but not by BTN3A1 triggering. Thus, we provide new insights into the CD277 co-stimulatory pathway that may differentially participate in the regulation of various cell-mediated immune responses.
Databáze: OpenAIRE
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