Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence
| Autor: | Catalin M. Filipeanu, Mary W. Hulin, Johnny R. Porter, Peter J. Winsauer, Russell J. Amato |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Receptor complex
Neuroactive steroid Ethanol GABAA receptor business.industry Alcohol dependence lcsh:RM1-950 Dehydroepiandrosterone Alcohol abuse Alcohol Review Article Pharmacology medicine.disease chemistry.chemical_compound lcsh:Therapeutics. Pharmacology chemistry nervous system medicine polycyclic compounds Molecular Medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Advances in Pharmacological Sciences, Vol 2011 (2011) Advances in Pharmacological Sciences |
| ISSN: | 1687-6342 1687-6334 |
| Popis: | Despite the prevalence of alcohol abuse and dependence in the US and Europe, there are only five approved pharmacotherapies for alcohol dependence. Moreover, these pharmacotherapeutic options have limited clinical utility. The purpose of this paper is to present pertinent literature suggesting that both alcohol and the neurosteroids interact at the GABAAreceptor complex and that the neurosteroid sites on this receptor complex could serve as new targets for the development of novel therapeutics for alcohol abuse. This paper will also present data collected by our laboratory showing that one neurosteroid in particular, dehydroepiandrosterone (DHEA), decreases ethanol intake in rats under a variety of conditions. In the process, we will also mention relevant studies from the literature suggesting that both particular subtypes and subunits of the GABAAreceptor play an important role in mediating the interaction of neurosteroids and ethanol. |
| Databáze: | OpenAIRE |
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