Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis
| Autor: | Noaya Ikeda, Yukimi Tanaka, Toyoki Kobayashi, Tomoko Hirao, Takashi Nakamura, Chiho Ohbayashi, Masayuki Sho, Kohei Morita, Tomoyo Yokotani, Tomomi Fujii |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Receptor ErbB-2 Breast surgery medicine.medical_treatment Breast Neoplasms chemical and pharmacologic phenomena 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Breast cancer Surgical oncology Internal medicine Humans Medicine Chemotherapy business.industry Tumor-infiltrating lymphocytes Axillary Lymph Node Dissection hemic and immune systems General Medicine medicine.disease Primary tumor Neoadjuvant Therapy Ki-67 Antigen Treatment Outcome Hormone receptor Lymphatic Metastasis 030220 oncology & carcinogenesis Axilla Female 030211 gastroenterology & hepatology Surgery Lymph Nodes business Forecasting |
| Zdroj: | Surgery Today. 51:595-604 |
| ISSN: | 1436-2813 0941-1291 |
| DOI: | 10.1007/s00595-020-02157-6 |
| Popis: | We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +). The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis. We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p |
| Databáze: | OpenAIRE |
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