CORRELATION BETWEEN INHIBITION, WORKING MEMORY AND DELIMITED FRONTAL AREA BLOOD FLOW MEASURED BY 99mTc-BICISATE SPECT IN ALCOHOL-DEPENDENT PATIENTS
| Autor: | Catherine Hanak, Xavier Noël, Rita Sferrazza, Jacques De Mol, Philippe Martin, Paul Verbanck, Jacques Paternot, Charles Kornreich, Michel Verhas, Isidore Pelc, Martial Van der Linden |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Elementary cognitive task Alcohol Drinking Neuropsychological Tests Single-photon emission computed tomography Severity of Illness Index Internal medicine medicine Humans Memory disorder Tomography Emission-Computed Single-Photon Memory Disorders medicine.diagnostic_test Working memory Cognitive disorder Neuropsychology Technetium Neural Inhibition General Medicine Frontal gyrus medicine.disease Frontal Lobe Cerebral blood flow Cerebrovascular Circulation Cardiology Radiopharmaceuticals Cognition Disorders Psychology Neuroscience |
| Zdroj: | Alcohol and Alcoholism. 36:556-563 |
| ISSN: | 1464-3502 |
| DOI: | 10.1093/alcalc/36.6.556 |
| Popis: | — Recently detoxified non-neurological alcoholic patients appear to be impaired in cognitive tasks measuring inhibitory processes as well as working memory (involving storage and manipulation of information). The aim of this study was to investigate in alcoholic participants the relationship between these two cognitive functions and regional cerebral blood flow (rCBF) studied at rest in regions of interest selected on the basis of recent PET studies which explored inhibitory and working memory in normal subjects. Twenty non-neurological alcoholic patients and 20 normal volunteers were selected for a neuropsychological exploration, including assessment of inhibition processes (by means of the Hayling test) and working memory (by means of the Alpha-span task). rCBF of alcoholics was also evaluated with a semi-quantitative method using a 99mTc-Bicisate single photon emission computed tomography (SPECT) procedure. Alcoholic patients performed worse than controls in the alphabetical condition of the Alpha-span task (involving manipulation and storage of information), and on the Hayling test. Significant correlation emerged between inhibition performance and both the bilateral inferior (left BA 47, r = -0.40; right BA 47, r = -0.599) and median frontal gyrus (left BA 10, r = -0.55; right BA 10, r = -0.59), but not with the region of reference (occipital/cerebellum, r = -0.13). Coordination of storage and manipulation was correlated with bilateral median frontal (left BA 10/46, r = -0.50; right BA 10/46, r = -0.45), but not with bilateral parietal area (left BA 7, r = -0.12, right BA 7, r = -0.18). These results suggest a relationship between inhibition and working memory deficits in alcoholic patients, and regional rCBF measured in frontal areas. Clinical implications of these data related to alcohol relapse are discussed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|